68Ga-DOTATATE PET Identifies Residual Myocardial Inflammation and Bone Marrow Activation After Myocardial Infarction

Systemic inflammation after myocardial infarction.

Bone Marrow Stem Cells for Myocardial Infarction

When news broke in 2001 that bone marrow– derived stem cells (BMCs) regenerate cardiac myocytes after myocardial infarction (MI), the prospects of regenerative therapy suddenly dawned on the horizon of cardiovascular medicine. Along with reports about differentiation of BMCs into neurons, hepatocytes, and muscle,1–4 BMCs delivered to the heart were shown to transdifferentiate into cardiac myocy...

SERUM IgE AND BETA 2 MICROGLOBULIN LEVELS AFTER MYOCARDIAL INFARCTION

Serum IgE and beta 2 microglobulin levels were determined in 31 patients suffering from acute myocardial infarction and 30 patients with other forms of ischemic heart disease. The levels of these parameters were studied on the first, third and seventh day after the onset of disease. The immunological method used for the determinations was ELISA Patients with myocardial infarction showed an...

Detection of Atherosclerotic Inflammation by 68Ga-DOTATATE PET Compared to [18F]FDG PET Imaging

BACKGROUND Inflammation drives atherosclerotic plaque rupture. Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography ([18F]FDG PET), [18F]FDG lacks cell specificity, and coronary imaging is unreliable because of myocardial spillover. OBJECTIVES This study tested the efficacy of gallium-68-labeled DOTATATE (68Ga-DOTATATE), a somatostati...

Application of 68Ga-PRGD2 PET/CT for αvβ3-integrin Imaging of Myocardial Infarction and Stroke

PURPOSE Ischemic vascular diseases, including myocardial infarction (MI) and stroke, have been found to be associated with elevated expression of αvβ3-integrin, which provides a promising target for semi-quantitative monitoring of the disease. For the first time, we employed (68)Ga-S-2-(isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid-PEG3-E[c(RGDyK)]2 ((68)Ga-PRGD2) to evalua...